Synthesis and characterization of New Derivatives from Ninhydrin and Isothiocyanate and Study of their Biological Effect

Abstract

A chemical structure was obtained biologically effective from Ninhydrin and Isothiocyanate derivatives. At the first stage of the synthesis, Isothiocyanate was combined with Hydrazine to obtain Hydrazine derivatives, and then its reactivity in the second stage with Ninhydrin and obtaining new derivatives of the Schiff bases. At the third stage, Dimethylacetylene Dicarboxylate (DAMD)was added to the prepared Schiff bases and Oxothiazolidine derivatives were obtained. The prepared compounds were characterized using proton nuclear magnetic resonance (¹H NMR), Mass spectrometry, and infrared spectroscopy (FT-IR). The biological activity of these compounds also was studied at a series of concentrations against Gram- negative bacteria, Escherichia coli, and Gram- positive bacteria, Staphylococcus Aureus. Using the diffusion method, some compounds showed biological effect ranges from medium to good on these germs