Synthesis and characterization of New Derivatives of Thiazolidines-4-One and Study of their Biological Effect

Abstract

New derivatives of Thiazolidines-4-One were synthesized from ninhydrin, isothiocyanate derivatives, and hydrazine, with the aim of obtaining a biologically active chemical structure. The synthesis took place in several stages. Proceeding from obtaining hydrazine derivatives, then its interaction with ninhydrin to get the new derivatives of Schiff base. The last stage, the prepared derivatives were condensed with dimethyl acetylene dicarboxylate (DAMD) and thiazolidine derivatives were obtained. The prepared compounds were characterized using proton nuclear magnetic resonance (¹H NMR), Mass spectrometry, and infrared spectroscopy (FT-IR). The biological activity of these compounds also was studied at a series of concentrations against Gram- negative bacteria, Escherichia coli, and Gram- positive bacteria, Staphylococcus aureus. Using the diffusion method, some compounds showed biological effect ranges from medium to good on these germs.